EV
01 / 04 Anti-Pigmentation
HYALU SERUM
UBIK
30ML
Clinical Efficacy Markers
- Hyaluronic Acid (multi-weight)
The Science of Anti-Pigmentation
UBIK HYALU SERUM (30ML)
Drug Facts
INGREDIENT · HUMECTANT, HYDRATING AGENT
Sodium Hyaluronate
also known as Hyaluronic Acid Sodium Salt
Function
May help support skin hydration and moisture retention through hygroscopic properties
How it works
Sodium hyaluronate is a sodium salt of hyaluronic acid that may help bind water molecules in the stratum corneum and dermis, potentially enhancing skin hydration. Research indicates it can penetrate the skin barrier when formulated with appropriate adjuvants and amino acids. Studies suggest the ingredient maintains structural stability during gastrointestinal transit and may exert antioxidant and anti-inflammatory effects when combined with complementary actives. The molecule's ability to modulate CD44 receptor expression has been shown in in vitro keratinocyte models.
⚑ For Indian skin (Fitzpatrick IV–VI)
Sodium hyaluronate has been shown to support hydration in deeper skin tones where transepidermal water loss may be elevated, particularly relevant in Kerala's humid tropical climate where excessive moisture can paradoxically lead to dehydration due to osmotic stress. Research indicates the ingredient does not increase melanin synthesis or phototoxic potential in Fitzpatrick IV-VI skin types. However, formulations should be carefully evaluated as combination products (particularly those with amino acids or cross-linked derivatives) may require stability testing under tropical humidity and heat conditions to prevent degradation. Clinical consideration should be given to post-inflammatory hyperpigmentation risk with injectable formulations in darker skin types, requiring careful injection technique and avoidance of trauma.
Effective concentration
0.1–2 %w/w (optimal ~0.5%w/w)
Clinical evidence
Research indicates that sodium hyaluronate combined with amino acids (glycine, alanine, proline) may enhance moisturizing performance compared to mono-component formulations. Studies suggest this combination strategy may reduce dosing frequency and improve hydration efficacy in skin rejuvenation applications.
Not specified in abstract Journal of Cosmetic Dermatology. 2026. PubMed →
Research suggests that hyaluronic acid derivatives demonstrate high structural stability across gastrointestinal stages and may exert superior antioxidant and anti-inflammatory activity. Studies indicate efficient intestinal barrier penetration without increased enzymatic degradation, with potential upregulation of CD44 receptor expression in keratinocytes.
Not specified in abstract Foods (Basel, Switzerland). 2026. PubMed →
Studies indicate sodium hyaluronate can be successfully formulated in hydrogel systems with complementary ingredients such as xanthan gum, demonstrating adequate physical and microbiological stability over extended storage periods. Research suggests these formulations maintain tunable rheological properties suitable for dermal administration.
Not specified in abstract Gels (Basel, Switzerland). 2026. PubMed →
Pairs well with
Glycerin · Propylene Glycol · Amino Acids (Glycine, Alanine, Proline) · Xanthan Gum · Panthenol · Niacinamide · Ceramides · Lactic Acid
Avoid combining with
High concentrations of alcohol (may cause osmotic dehydration) · Strong chemical exfoliants at high pH (may impair hyaluronic acid stability) · BDDE cross-linked derivatives in certain formulations (safety considerations)
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