PRF (Platelet-Rich Fibrin) is a second-generation platelet concentrate that uses a natural fibrin matrix to deliver sustained, slow-release growth factors to hair follicles over 7–14 days — far longer than the rapid burst release of PRP. Developed by Dr. Choukroun in 2001, PRF is prepared from your blood with zero chemical additives or anticoagulants, making it the most natural regenerative hair therapy available. At DermaVue, board-certified dermatologists administer i-PRF using optimised low-speed centrifugation protocols. Treatment requires 3–6 sessions monthly. Available at all 7 DermaVue clinics across Kerala and Coimbatore.
PRF uses the body's natural clotting mechanism. When blood is centrifuged without anticoagulants, fibrinogen converts to fibrin mesh that traps platelets, leukocytes, macrophages, and stem cells. This fibrin matrix releases growth factors over 7–14 days vs PRP's single burst.
| Feature | PRP | GFC | PRF |
|---|---|---|---|
| Anticoagulants | Required (citrate) | Activation solution | None |
| Growth factor release | Rapid burst | Moderate sustained | Slow sustained (7–14 days) |
| Fibrin matrix | Absent | Absent | Present — natural scaffold |
| Additives | Chemical | Chemical activator | Zero |
| Leukocytes | Variable | Absent | Present (beneficial) |
| Preparation time | 30–45 min | 40–50 min | Under 10 min |
10–15 ml collected without anticoagulant — the key distinction from PRP preparation.
700 rpm for 3 minutes using the LSCC (Low-Speed Centrifugation Concept) protocol to preserve cells and growth factors.
Three layers form after centrifugation. The i-PRF layer — rich in platelets, leukocytes, and stem cells — is carefully aspirated.
Liquid PRF is injected intradermally into thinning scalp areas before full polymerisation, creating a slow-release growth factor depot in the tissue.
Total time: Under 30 minutes. All procedures performed by board-certified dermatologists at DermaVue.
Protocol: 3–6 sessions monthly. Each session takes under 30 minutes.
Initial reduction in hair fall; follicular stimulation begins
Visible improvement on trichoscopy; new vellus hairs appear
Progressive thickening; measurable increase in hair density and shaft diameter
Continued improvement with maintenance sessions every 3–6 months
Maintenance: Every 3–6 months. PRF's fibrin matrix means longer intervals may be possible compared to PRP.
| Package | Cost (Approx.) | Details |
|---|---|---|
| Single i-PRF session | ₹5,000–₹12,000 | Blood draw, centrifugation, injection |
| Standard course (4 sessions) | ₹18,000–₹45,000 | Monthly sessions |
| PRF + Microneedling combo | ₹7,000–₹15,000/session | Enhanced delivery |
| Maintenance session | ₹5,000–₹10,000 | Every 3–6 months |
| Consultation | Starting ₹300 | Includes trichoscopy |
PRF offers excellent value as the most natural regenerative option with zero chemical additives. Costs vary by clinic location and extent of treatment area.
Slow-release growth factors. Zero additives. Fibrin matrix technology. Under 30 minutes. Board-certified dermatologist-administered at all 7 DermaVue locations.