The IJDVL 'Standard Guidelines of Care for Chemical Peels', a cornerstone publication for Indian dermatology practice, categorises chemical peels by depth: very superficial (stratum corneum only), superficial light (full epidermis), and medium (upper reticular dermis). Deep phenol-based peels are essentially not used in Fitzpatrick IV-VI skin due to unacceptable hypopigmentation risk.
Agent-by-depth selection for South Asian skin: salicylic acid 20-30% is lipophilic, particularly effective for active acne + comedonal blackheads, with the lowest PIH risk among peeling acids in Fitzpatrick IV-VI. Glycolic acid 50-70% is the alpha-hydroxy workhorse, effective for fine wrinkles, mild PIH, melasma adjunct, but requires time-controlled application (neutralised at 3-5 minutes). TCA 10-30% is superficial at 10-15% and medium-depth at 20-30%, effective for deeper PIH, acne scars, photoaging, but carries higher PIH risk in Fitzpatrick IV-VI and is used cautiously with adequate 2-4 week retinoid priming.
Jessner's solution (salicylic 14% + lactic 14% + resorcinol 14% in alcohol) is used as a primer before TCA (Jessner's + TCA combination protocol) to achieve uniform medium-depth penetration. Layer count (4-7 coats) determines depth. Mandelic acid 20-50% is the gentlest superficial peel, used as starter peel in very sensitive skin or in patients with active melasma + Fitzpatrick V-VI.
For melasma specifically (see § 2): peels are combined with triple-combination cream priming and low-fluence Q-switched Nd:YAG laser, not used as monotherapy. DermaVue's standard chemical-peel course is 4-6 sessions at 2-week intervals for superficial peels, 4-6 weeks for medium-depth, with photographic comparison between sessions and structured maintenance protocol after the active series.